Susan Hutson

Role of the essential branched chain amino acids (BCAA), leucine, isoleucine, valine, as nutritional signals influencing macronutrient (protein, carbohydrate, fat) choice, body composition, immune function, and inborn errors of BCAA metabolism (such as Maple Syrup Urine Disease).

Pub Med Publications

Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase. Tso SC, Gui WJ, Wu CY, Chuang JL, Qi X, Skvorak KJ, Dorko K, Wallace AL, Morlock LK, Lee BH, Hutson SM, Strom SC, Williams NS, Tambar UK, Wynn RM, Chuang DT. J Biol Chem. 2014 Jul 25;289(30):20583-20593. Epub 2014 Jun 3.

Cytosolic Branched Chain Aminotransferase (BCATc) Regulates mTORC1 Signaling and Glycolytic Metabolism in CD4+ T Cells. Ananieva EA, Patel CH, Drake CH, Powell JD, Hutson SM. J Biol Chem. 2014 Jul 4;289(27):18793-804. doi: 10.1074/jbc.M114.554113. Epub 2014 May 20.

Leucine acts in the brain to suppress food intake but does not function as a physiological signal of low dietary protein.Laeger T, Reed SD, Henagan TM, Fernandez DH, Tagahavi M, Addington A, Munzberg H, Martin RJ, Hutson SM, Morrison CD. Am J Physiol Regul Integr Comp Physiol. 2014 Jun 4. pii: ajpregu.00116.2014. [Epub ahead of print]

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1.Tönjes M, Barbus S, Park YJ, Wang W, Schlotter M, Lindroth AM, Pleier SV, Bai AH, Karra D, Piro RM, Felsberg J, Addington A, Lemke D, Weibrecht I, Hovestadt V, Rolli CG, Campos B, Turcan S, Sturm D, Witt H, Chan TA, Herold-Mende C, Kemkemer R, König R, Schmidt K, Hull WE, Pfister SM, Jugold M, Hutson SM, Plass C, Okun JG, Reifenberger G, Lichter P, Radlwimmer B. Nat Med. 2013 Jul;19(7):901-8. doi: 10.1038/nm.3217.

Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase. Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, Chuang DT. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9728-33

Expression of mitochondrial branched-chain aminotransferase and α-keto-acid dehydrogenase in rat brain: implications for neurotransmitter metabolism.
Cole JT, Sweatt AJ, Hutson SM. Front Neuroanat. 2012;6:18. Epub 2012 May 28. 

Nutrition strategies to improve physical capabilities in Duchenne muscular dystrophy. Davoodi J, Markert CD, Voelker KA, Hutson SM, Grange RW. Phys Med Rehabil Clin N Am. 2012 Feb;23(1):187-99, xii-xiii. Epub 2011 Dec 13. Review.

Impaired branched chain amino acid metabolism alters feeding behavior and increases orexigenic neuropeptide expression in the hypothalamus. Purpera MN, Shen L, Taghavi M, Münzberg H, Martin RJ, Hutson SM, Morrison CD. J Endocrinol. 2012 Jan;212(1):85-94.

Interaction between glutamate dehydrogenase (GDH) and l-leucine catabolic enzymes: Intersecting metabolic pathways. Hutson SM, Islam MM, Zaganas I. Neurochem Int. 2011 Sep;59(4):518-24.

1980, Postdoctoral, Nutritional Sciences/Biochemistry, University of Wisconsin-Madison

1976, Ph.D., Biochemistry, University of Wisconsin-Madison

1970, B.A., Molecular Science, Vanderbilt University