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Craige Lab

The Craige Lab investigates how cells respond to diet, exercise, and disease through reactive oxygen species (ROS) signaling, aiming to develop targeted therapies for cardiometabolic health.

A group of students and faculty wearing masks and lab coats stand in a lab for a photo.

The major focus of our research is understanding how cells/tissues communicate with each other to sense and respond to environmental changes (e.g., diet, exercise, disease, etc.).While diet and exercise are known to play a significant role in cardiometabolic diseases, the molecular signaling underpinning their influence is only beginning to come to light.

For all organisms that live in aerobic conditions, reactive oxygen species (ROS) are continuously produced. ROS can damage biological macromolecules such as proteins, lipids, DNA, and RNA; however, in discrete times and places, a localized increase in ROS production serves as an immediate signal to adapt to environmental changes.

We aim to elucidate the mechanisms by which diet and exercise influence ROS signaling and result in either promotion or prevention of cardiometabolic diseases. Our laboratory has identified a critical role for reactive oxygen species (ROS) signaling in both adaptive and maladaptive responses to diet and exercise. Understanding these molecular pathways will pave the way for targeted therapies in cardiometabolic disease.

Principal Investigator

  • Bio Item
    Siobhan Craige, PhD , bio

    Assistant Professor: Exercise metabolism; redox signaling in health and disease; vascular influence on diet and exercise

Lab Manager